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CS-W001157 4
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1-(4-(Chloromethyl)phenyl)-1H-pyrazole

  • CAS No. 143426-52-2

  • Cat. No. CS-0046907
  • Molecule weight192.64
  • Purity≥95%
  • MDL No.MFCD07366379

*For research and further manufacturing use only, not for direct human use.

1-(4-(Chloromethyl)phenyl)-1H-pyrazole|CS-0046907

Structure of 143426-52-2

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General Information

  • CAS No. 143426-52-2
  • Cat. No. CS-0046907
  • Purity ≥95%
  • MDL No. MFCD07366379
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉ClN₂
  • Molecular Weight 192.64
  • Synonym(s) 1-[4-(chloromethyl)phenyl]-1H-pyrazole
  • SMILES ClCC1=CC=C(N2N=CC=C2)C=C1

Description

1-(4-(Chloromethyl)phenyl)-1H-pyrazole features a reactive chloromethyl group positioned para to the pyrazole core, enabling straightforward functionalization in cross-coupling and conjugation workflows. This bench-stable scaffold integrates readily into bioconjugates and pharmaceutical intermediates, offering high reactivity without compromising handling safety under standard conditions.

Application

1-(4-(Chloromethyl)phenyl)-1H-pyrazole serves as a versatile bifunctional building block, enabling efficient coupling reactions via its pendant chloromethyl group. The pyrazole core provides stability and orthogonal reactivity, facilitating downstream modifications in medicinal chemistry and materials synthesis. Its bench-stable nature and compatibility with nucleophilic substitution protocols make it well-suited for modular scaffold construction.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.6111
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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