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CS-W001157 4
Total: USD 88.00

4-(1H-Pyrazol-1-yl)benzenemethanol

  • CAS No. 143426-49-7

  • Cat. No. CS-0029515
  • Purity≥98%
  • MDL No.MFCD02682057

*For research and further manufacturing use only, not for direct human use.

4-(1H-Pyrazol-1-yl)benzenemethanol|CS-0029515

Structure of 143426-49-7

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General Information

  • CAS No. 143426-49-7
  • Cat. No. CS-0029515
  • Purity ≥98%
  • MDL No. MFCD02682057
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀N₂O
  • Molecular Weight 174.20
  • Synonym(s) 4-(Pyrazol-1-yl)benzyl alcohol; [4-(1H-Pyrazol-1-yl)phenyl]methanol; 4-(1H-Pyrazol-1-yl)benzyl alcohol
  • SMILES OCC1=CC=C(N2N=CC=C2)C=C1

Description

4-(1H-Pyrazol-1-yl)benzenemethanol features a pyrazole ring directly linked to a phenylmethanol scaffold, delivering a versatile pharmacophore for medicinal chemistry. The electron-rich pyrazole moiety enhances hydrogen bonding capacity, while the benzylic alcohol offers a handle for derivatization. This compound exhibits excellent bench stability and solubility in common organic solvents, facilitating use in synthetic transformations and screening campaigns.

Application

4-(1H-Pyrazol-1-yl)benzenemethanol serves as a versatile building block for medicinal chemistry and materials science, enabling the construction of bioactive heterocycles and functionalized aryl systems. The pyrazole moiety provides enhanced metabolic stability and hydrogen-bonding capacity, while the benzylic alcohol facilitates downstream transformations such as oxidation, etherification, or esterification. Its bench-stable nature and compatibility with common coupling reactions make it a practical choice for iterative synthesis campaigns in API development and molecular diversification.

Synthesis

  • Route1
    • Ethyl 4-(1H-pyrazol-1-yl)benzoate|CS-0313703
      143426-47-5
    • ~89%
    • In-stock
      4-(1H-Pyrazol-1-yl)benzenemethanol|CS-0029515
      143426-49-7

    References

    • Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
  • Route2

    References

    • European Journal of Medicinal Chemistry, , vol. 27, # 3 p. 219 - 228

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.3646
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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