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CS-W001157 4
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(S)-2-((tert-Butoxycarbonyl)amino)-4-cyclohexylbutanoic acid

  • CAS No. 143415-51-4

  • Cat. No. CS-0372317
  • Purity≥97%
  • MDL No.MFCD18252746

*For research and further manufacturing use only, not for direct human use.

(S)-2-((tert-Butoxycarbonyl)amino)-4-cyclohexylbutanoic acid|CS-0372317

Structure of 143415-51-4

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General Information

  • CAS No. 143415-51-4
  • Cat. No. CS-0372317
  • Purity ≥97%
  • MDL No. MFCD18252746
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₇NO₄
  • Molecular Weight 285.38
  • Synonym(s) Carfilzomib Impurity 28
  • SMILES CC(C)(C)OC(N[C@H](C(O)=O)CCC1CCCCC1)=O

Description

This chiral building block features a protected amine and a cyclohexyl-substituted aliphatic chain, enabling direct incorporation into peptide syntheses. The tert-butyl carbamate group ensures stability during manipulations, while the (S)-configuration provides stereochemical control in complex molecule assembly.

Application

(S)-2-((tert-Butoxycarbonyl)amino)-4-cyclohexylbutanoic acid serves as a versatile chiral building block for peptide and peptidomimetic synthesis. The protected amine and carboxylic acid functionalities enable sequential coupling reactions under standard conditions, while the cyclohexyl group provides steric bulk and conformational rigidity. Bench-stable and readily purified by chromatography, it facilitates the construction of complex scaffolds in medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   3.3248
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   5

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