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8-Bromo-6-chloro-[1,2,4]triazolo[1,5-a]pyridine

  • CAS No. 1433822-19-5

  • Cat. No. CS-0157335
  • Molecule weight232.47
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

8-Bromo-6-chloro-[1,2,4]triazolo[1,5-a]pyridine|CS-0157335

Structure of 1433822-19-5

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General Information

  • CAS No. 1433822-19-5
  • Cat. No. CS-0157335
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClN₃
  • Molecular Weight 232.47
  • Synonym(s) 8-Bromo-6-chloro[1,2,4]triazolo[1,5-a]pyridine
  • SMILES C1=C(C2=NC=NN2C=C1Cl)Br

Description

8-Bromo-6-chloro-[1,2,4]triazolo[1,5-a]pyridine features a fused triazolopyridine core bearing bromo and chloro substituents at positions 8 and 6, respectively. This electron-deficient heterocycle serves as a high-reactivity scaffold for transition metal-catalyzed cross-coupling reactions. The strategic placement of halogens enables sequential functionalization, facilitating the rapid assembly of complex molecular architectures in medicinal chemistry and materials science applications.

Application

8-Bromo-6-chloro-[1,2,4]triazolo[1,5-a]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its dual halogen substituents enable palladium-catalyzed cross-coupling reactions, facilitating the construction of complex biaryl and heteroaryl architectures. The molecule exhibits good bench stability and compatibility with diverse reaction conditions, supporting efficient functionalization in multistep syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   2.1452
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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