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CS-W001157 4
Total: USD 88.00

1-(4-Bromophenyl)cyclopentane-1-carboxylic acid

  • CAS No. 143328-24-9

  • Cat. No. CS-0046988
  • Purity≥97%
  • MDL No.MFCD00455267

*For research and further manufacturing use only, not for direct human use.

1-(4-Bromophenyl)cyclopentane-1-carboxylic acid|CS-0046988

Structure of 143328-24-9

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General Information

  • CAS No. 143328-24-9
  • Cat. No. CS-0046988
  • Purity ≥97%
  • MDL No. MFCD00455267
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₃BrO₂
  • Molecular Weight 269.13
  • Synonym(s) 1-(4-Bromophenyl)cyclopentanecarboxylic acid
  • SMILES O=C(C1(C2=CC=C(Br)C=C2)CCCC1)O

Description

This cyclopentane carboxylic acid derivative features a para-brominated phenyl group, offering enhanced electron-withdrawing character and improved solubility in organic media. The rigid cyclopentane scaffold provides conformational stability, while the carboxylic acid functionality enables direct coupling reactions. Ideal for medicinal chemistry scaffolds and pharmaceutical intermediates requiring halogenated aromatic handles.

Application

1-(4-Bromophenyl)cyclopentane-1-carboxylic acid serves as a versatile building block for medicinal chemistry and materials synthesis, enabling efficient construction of biaryl-containing scaffolds via palladium-catalyzed cross-coupling. The carboxylic acid functionality offers direct handle for derivatization, while the bromophenyl group provides orthogonal reactivity in Suzuki, Stille, or Negishi coupling reactions. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows requiring functional group tolerance and predictable reactivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   3.3455
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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