1-(3-Chlorophenyl)cyclopentane-1-carboxylic acid

Name: 1-(3-Chlorophenyl)cyclopentane-1-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 143328-21-6
Cat. No. CS-0044935
Purity≥98%
MDL No.MFCD03161248

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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1-(3-Chlorophenyl)cyclopentane-1-carboxylic acid|CS-0044935

Structure of 143328-21-6

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General Information

CAS No. 143328-21-6
Cat. No. CS-0044935
Purity ≥98%
MDL No. MFCD03161248
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₃ClO₂
Molecular Weight 224.68
Synonym(s) 1-(3-CHLOROPHENYL)CYCLOPENTANECARBOXYLIC ACID
SMILES O=C(C1(C2=CC=CC(Cl)=C2)CCCC1)O

Description

This cyclopentane carboxylic acid derivative features a 3-chlorophenyl group directly attached to the cyclopentane ring, delivering enhanced lipophilicity and metabolic stability. The electron-withdrawing chlorine substituent modulates reactivity and influences binding affinity in target-directed synthesis. Ideal for medicinal chemistry applications requiring rigid, aromatic-aliphatic scaffolds with tunable physicochemical properties.

Application

1-(3-Chlorophenyl)cyclopentane-1-carboxylic acid serves as a versatile building block for medicinal chemistry campaigns, enabling the construction of bioactive scaffolds through standard functional group transformations. Its cyclopentane core provides conformational rigidity, while the 3-chlorophenyl moiety offers enhanced lipophilicity and potential for π–π interactions. The carboxylic acid functionality facilitates derivatization via amide coupling, esterification, or salt formation, supporting downstream synthetic pathways in API development. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthesis workflows.

Synthesis

Route1
- In-stock
  
  143328-16-9
- ~75%
- In-stock
  
  143328-21-6
References
- Mndzhoyan, Sh. L.; Kramer, M. S.; Akopyan, S. G.; Grigoryan, M. M.; Ter-Zakharyan, Yu. Z.; et al. Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 169 - 173 Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 54 - 56
Route2
- In-stock
  
  1529-41-5
- ~%
- In-stock
  
  143328-21-6
References
- Pharmaceutical Chemistry Journal, , vol. 26, # 2 p. 169 - 173 Khimiko-Farmatsevticheskii Zhurnal, , vol. 26, # 2 p. 54 - 56

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 37.3
LogP 3.2364
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-(3-Chlorophenyl)cyclopentane-1-carboxylic acid

CAS No. 143328-21-6

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