N,N-Diethylpiperidin-4-amine

Name: N,N-Diethylpiperidin-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 143300-64-5
Cat. No. CS-W022906
Purity≥98%
MDL No.MFCD04971982

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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General Information

CAS No. 143300-64-5
Cat. No. CS-W022906
Purity ≥98%
MDL No. MFCD04971982
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₂₀N₂
Molecular Weight 156.27
Synonym(s) Diethyl-Piperidin-4-YL-AMINE
SMILES CCN(CC)C1CCNCC1

Description

N,N-Diethylpiperidin-4-amine features a tertiary amine center flanked by two ethyl groups, delivering high nucleophilicity and enhanced solubility in organic solvents. This piperidine derivative serves as a robust catalyst in C–N bond-forming reactions and integrates efficiently into complex molecular architectures under mild conditions.

Application

N,N-Diethylpiperidin-4-amine serves as a versatile tertiary amine scaffold in medicinal chemistry, enabling efficient formation of secondary and tertiary amines via alkylation or reductive amination. Its piperidine core provides favorable solubility and metabolic stability, while the diethyl substitution enhances nucleophilicity and steric profile. This compound functions effectively as a building block for bioactive heterocycles and API intermediates, offering robust bench stability and compatibility with standard synthetic workflows.

Synthesis

Route1
- 79099-07-3
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- In-stock
  
  143300-64-5
References
- Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 23 p. 5841 - 5844

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 15.27
LogP 1.0802
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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N,N-Diethylpiperidin-4-amine

CAS No. 143300-64-5

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