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CS-W001157 4
Total: USD 88.00

3-Methoxy-N-methylaniline

  • CAS No. 14318-66-2

  • Cat. No. CS-0301378
  • Purity≥95%
  • MDL No.MFCD05665953

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-N-methylaniline|CS-0301378

Structure of 14318-66-2

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General Information

  • CAS No. 14318-66-2
  • Cat. No. CS-0301378
  • Purity ≥95%
  • MDL No. MFCD05665953
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁NO
  • Molecular Weight 137.18
  • Synonym(s) N-methyl-m-anisidine
  • SMILES CNC1=CC(=CC=C1)OC

Description

3-Methoxy-N-methylaniline is a bench-stable, electron-rich aromatic amine featuring a para-methoxy group and a N-methyl substitution. This combination enhances nucleophilicity while improving solubility in organic solvents. The molecule integrates readily into coupling reactions and serves as a key intermediate for pharmaceuticals, agrochemicals, and functional dyes.

Application

3-Methoxy-N-methylaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering a balanced combination of electron-donating methoxy and N-methylamino groups. Its stability under standard reaction conditions enables reliable use in electrophilic aromatic substitution, Suzuki coupling, and reductive amination workflows. The compound facilitates efficient access to substituted anilines and heterocyclic scaffolds commonly found in bioactive molecules, with straightforward purification via distillation or chromatography.

Synthesis

  • Route1
    • null|null
      50-00-0
    • null|null
      536-90-3
    • ~85%
    • In-stock
      3-Methoxy-N-methylaniline|CS-0301378
      14318-66-2

    References

    • Kamino, Shinichiro; Murakami, Miho; Tanioka, Masaru; Shirasaki, Yoshinao; Watanabe, Keiko; Horigome, Jun; Ooyama, Yousuke; Enomoto, Shuichi Organic Letters, 2014 , vol. 16, # 1 p. 258 - 261
  • Route2
    • null|null
      27153-17-9
    • ~%
    • In-stock
      3-Methoxy-N-methylaniline|CS-0301378
      14318-66-2

    References

    • Tetrahedron, , vol. 27, p. 1253 - 1259
  • Route3
    • null|null
      123767-44-2
    • ~80%
    • In-stock
      3-Methoxy-N-methylaniline|CS-0301378
      14318-66-2

    References

    • Lopez, Francisco J.; Nitzan, Dov Tetrahedron Letters, 1999 , vol. 40, # 11 p. 2071 - 2074

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   1.7369
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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