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(1R,3R)-3-{[(tert-Butoxy)carbonyl]amino}cyclohexane-1-carboxylic acid

  • CAS No. 1430938-32-1

  • Cat. No. CS-0053618
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(1R,3R)-3-{[(tert-Butoxy)carbonyl]amino}cyclohexane-1-carboxylic acid|CS-0053618

Structure of 1430938-32-1

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General Information

  • CAS No. 1430938-32-1
  • Cat. No. CS-0053618
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₄
  • Molecular Weight 243.30
  • Synonym(s) (1R,3R)-3-Boc-amino-cyclohexanecarboxylic acid
  • SMILES CC(C)(C)OC(=O)N[C@@H]1CCC[C@H](C1)C(O)=O

Description

This cyclohexane-based amino acid derivative features a tert-butoxycarbonyl-protected amine and a carboxylic acid group, enabling direct incorporation into peptide synthesis workflows. The stereochemistry at the 1- and 3-positions ensures high diastereoselectivity in coupling reactions, while the bulky tert-butyl group provides steric shielding and enhanced stability during handling.

Application

(1R,3R)-3-{[(tert-Butoxy)carbonyl]amino}cyclohexane-1-carboxylic acid serves as a stereochemically defined building block for cyclohexane-based peptidomimetics and bioactive scaffolds. The Boc-protected amine and carboxylic acid functionalities enable sequential coupling and orthogonal deprotection, facilitating efficient synthesis of complex targets. Its bench-stable nature and compatibility with standard peptide coupling protocols make it well-suited for medicinal chemistry campaigns requiring conformationally constrained intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   2.1545
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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