Lot numbers can be found on the outside label of a product:
Boc-NH-PEG1-CH2COOH
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CAS No. 142929-49-5
- Cat. No. CS-0115466
- Purity≥97%
- MDL No.MFCD14155965
*For research and further manufacturing use only, not for direct human use.
Structure of 142929-49-5
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General Information
- CAS No. 142929-49-5
- Cat. No. CS-0115466
- Purity ≥97%
- MDL No. MFCD14155965
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₇NO₅
- Molecular Weight 219.23
- Synonym(s) None
- SMILES O=C(O)COCCNC(OC(C)(C)C)=O
Description
Boc-NH-PEG1-CH2COOH features a C1 polyethylene glycol spacer flanked by a tert-butoxycarbonyl-protected amine and a carboxylic acid terminus. This bifunctional scaffold enables facile conjugation in bioconjugation workflows, offering enhanced solubility and stability under standard conditions.
Application
Boc-NH-PEG1-CH2COOH serves as a versatile bifunctional linker for peptide and biomolecule conjugation. The Boc group provides stable protection of the amine, while the terminal carboxylic acid enables direct coupling to amines or activation via standard esterification protocols. Its PEG1 spacer enhances solubility and reduces aggregation in aqueous environments, facilitating efficient purification and use in solid-phase synthesis and bioconjugation workflows.
Synthesis
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Route1
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In-stock
26690-80-2 -
79-11-8 - ~71%
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In-stock
142929-49-5
References
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MYREXIS, INC.; BAJJI, Ashok, C.; TANGALLAPALLY, Rajendra, P.; KIM, In, Chul; KIM, Se, Ho; PARKER, Daniel, P.; TROVATO, Richard; PAPAC, Damon, I.; YAGER, Kraig; BAICHWAL, Vijay, R. Patent: WO2012/148550 A1, 2012 ; Location in patent: Page/Page column 50; 51 ;
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Route2
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In-stock
142929-48-4 - ~71%
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In-stock
142929-49-5
References
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Chandrakumar; Stapelfeld; Beardsley; Lopez; Drury; Anthony; Savage; Williamson; Reichman Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2928 - 2938
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Route3
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142929-50-8
- ~75%
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In-stock
142929-49-5
References
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Adamczyk, Maciej; Fishpaugh, Jeffrey R.; Thiruvazhi, Mohan Organic Preparations and Procedures International, 2002 , vol. 34, # 3 p. 326 - 331
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 84.86
- LogP 0.6123
- H_Acceptors 4
- H_Donors 2
- Rotatable_Bonds 5
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Key Words
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