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CS-W001157 4
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Isobutylamido thiazolyl resorcinol

  • CAS No. 1428450-95-6

  • Cat. No. CS-0433783
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Isobutylamido thiazolyl resorcinol|CS-0433783

Structure of 1428450-95-6

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General Information

  • CAS No. 1428450-95-6
  • Cat. No. CS-0433783
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₄N₂O₃S
  • Molecular Weight 278.33
  • Synonym(s) None
  • SMILES O=C(C(C)C)NC1=NC(C2=C(O)C=C(O)C=C2)=CS1

Description

Isobutylamido thiazolyl resorcinol features a resorcinol core functionalized with a thiazole ring and a sterically hindered isobutylamido group, delivering enhanced solubility and metabolic stability. This combination enables efficient integration into bioactive scaffolds for medicinal chemistry applications, particularly in kinase inhibitor design and antifungal agent development.

Application

Isobutylamido thiazolyl resorcinol serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its resorcinol core provides orthogonal functionality for derivatization, while the thiazole ring offers structural rigidity and enhanced metabolic stability. The isobutylamido group contributes favorable lipophilicity and solubility balance, facilitating downstream functionalization and purification. This scaffold demonstrates robust bench stability and compatibility with standard coupling and protection protocols, making it well-suited for parallel synthesis campaigns and lead optimization workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   82.45
  • LogP   2.8158
  • H_Acceptors   5
  • H_Donors   3
  • Rotatable_Bonds   3

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