6-Bromo-4-fluoro-2-methylbenzo[d]thiazole

Name: 6-Bromo-4-fluoro-2-methylbenzo[d]thiazole
Brand: ChemScene
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CAS No. 1427433-65-5
Cat. No. CS-0527235
Molecule weight246.10
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Bromo-4-fluoro-2-methylbenzo[d]thiazole|CS-0527235

Structure of 1427433-65-5

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General Information

CAS No. 1427433-65-5
Cat. No. CS-0527235
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅BrFNS
Molecular Weight 246.10
Synonym(s) 6-Bromo-4-fluoro-2-methyl-1,3-benzothiazole
SMILES CC1=NC2=C(F)C=C(Br)C=C2S1

Description

6-Bromo-4-fluoro-2-methylbenzo[d]thiazole features a fused heterocyclic core with strategically positioned halogen and methyl substituents. This electron-deficient scaffold enables efficient coupling in cross-coupling reactions, particularly Pd-catalyzed variants. The bromine atom serves as a high-reactivity handle for C–C bond formation, while the fluorine enhances metabolic stability and modulates electronic properties. Bench-stable under standard conditions, it integrates readily into complex molecular architectures.

Application

6-Bromo-4-fluoro-2-methylbenzo[d]thiazole serves as a versatile building block in the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its orthogonal halogenation pattern enables selective cross-coupling reactions, while the methyl group provides a handle for further functionalization. The molecule exhibits excellent bench stability and compatibility with palladium-catalyzed transformations, facilitating efficient access to complex scaffolds in medicinal chemistry and process development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

TPSA 12.89
LogP 3.50632
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Benzothiazole compounds

Key Words

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6-Bromo-4-fluoro-2-methylbenzo[d]thiazole

CAS No. 1427433-65-5

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