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CS-W001157 4
Total: USD 88.00

5-Bromo-6-fluoro-2,3-dihydroisoindol-1-one

  • CAS No. 1427403-96-0

  • Cat. No. CS-0757968
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-6-fluoro-2,3-dihydroisoindol-1-one|CS-0757968

Structure of 1427403-96-0

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General Information

  • CAS No. 1427403-96-0
  • Cat. No. CS-0757968
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrFNO
  • Molecular Weight 230.03
  • Synonym(s) None
  • SMILES FC1=CC2=C(CNC2=O)C=C1Br

Description

5-Bromo-6-fluoro-2,3-dihydroisoindol-1-one features a fused heterocyclic core with complementary halogen substituents enabling selective cross-coupling and functionalization. This electron-deficient scaffold integrates readily into bioactive molecule design, offering enhanced metabolic stability and tunable polarity for medicinal chemistry applications.

Application

5-Bromo-6-fluoro-2,3-dihydroisoindol-1-one serves as a versatile building block for the synthesis of substituted isoindolinones, enabling efficient functionalization at the C5 and C6 positions. Its halogenated framework facilitates palladium-catalyzed cross-coupling reactions, while the lactam functionality provides stability and compatibility with diverse reaction conditions. This compound offers excellent bench stability and ease of purification, making it well-suited for medicinal chemistry campaigns and process development in API synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   1.8316
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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