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CS-W001157 4
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3-Fluoro-3-methylazetidine hydrochloride

  • CAS No. 1427379-42-7

  • Cat. No. CS-0051364
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-3-methylazetidine hydrochloride|CS-0051364

Structure of 1427379-42-7

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General Information

  • CAS No. 1427379-42-7
  • Cat. No. CS-0051364
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉ClFN
  • Molecular Weight 125.57
  • Synonym(s) 3-Fluoro-3-methylazetidine HCl
  • SMILES Cl.CC1(F)CNC1

Description

3-Fluoro-3-methylazetidine hydrochloride is a sterically constrained, bench-stable heterocyclic building block featuring a fluorinated methyl substituent. This configuration enhances metabolic stability and modulates electronic properties, enabling efficient incorporation into bioactive molecules. The hydrochloride salt ensures excellent solubility and handling convenience in synthetic workflows.

Application

3-Fluoro-3-methylazetidine hydrochloride serves as a valuable building block for medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds found in bioactive molecules. Its constrained azetidine ring enhances metabolic stability and modulates physicochemical properties. The hydrochloride salt ensures excellent solubility and bench stability, facilitating straightforward handling and purification in standard synthetic workflows. Functions effectively in nucleophilic substitution and coupling reactions with broad functional group tolerance.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   0.7396
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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