7-Bromo-4-chloroisoindolin-1-one

Name: 7-Bromo-4-chloroisoindolin-1-one
Brand: ChemScene
Availability: InStock
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CAS No. 1427357-41-2
Cat. No. CS-0533106
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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7-Bromo-4-chloroisoindolin-1-one|CS-0533106

Structure of 1427357-41-2

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General Information

CAS No. 1427357-41-2
Cat. No. CS-0533106
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅BrClNO
Molecular Weight 246.49
Synonym(s) None
SMILES O=C1NCC2=C1C(Br)=CC=C2Cl

Description

7-Bromo-4-chloroisoindolin-1-one is a halogenated isoindolinone scaffold featuring complementary electrophilic sites at the 7-bromo and 4-chloro positions. This electron-deficient core enables selective coupling reactions in synthetic organic chemistry, particularly in cross-coupling and transition-metal-catalyzed transformations. The molecule exhibits enhanced stability under standard bench conditions and serves as a valuable building block for complex heterocyclic architectures in medicinal chemistry and materials science.

Application

7-Bromo-4-chloroisoindolin-1-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of biologically relevant isoindolinone scaffolds. Its orthogonal halogen functionality facilitates late-stage diversification via Pd-catalyzed cross-coupling reactions. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, supporting scalable access to complex heterocyclic architectures.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 29.1
LogP 2.3459
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Drug Discovery Cancer HPK1

Key Words

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7-Bromo-4-chloroisoindolin-1-one

CAS No. 1427357-41-2

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