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2-(5-(Methoxycarbonyl)thiophen-2-yl)acetic acid

  • CAS No. 142667-06-9

  • Cat. No. CS-0061848
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(5-(Methoxycarbonyl)thiophen-2-yl)acetic acid|CS-0061848

Structure of 142667-06-9

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General Information

  • CAS No. 142667-06-9
  • Cat. No. CS-0061848
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈O₄S
  • Molecular Weight 200.21
  • Synonym(s) [5-(Methoxycarbonyl)-2-thienyl]acetic acid
  • SMILES COC(=O)C1=CC=C(CC(=O)O)S1

Description

This thiophene-based carboxylic acid features a methoxycarbonyl group enhancing solubility and reactivity. The acetic acid side chain enables direct coupling in synthesis, while the electron-deficient thiophene ring facilitates cross-coupling reactions. Bench-stable and moisture-tolerant, it serves as a key building block for heterocyclic pharmaceuticals and functional materials.

Application

2-(5-(Methoxycarbonyl)thiophen-2-yl)acetic acid serves as a versatile building block for thiophene-based heterocycles and bioactive molecule synthesis. Its pendant carboxylic acid and ester functionalities enable facile derivatization via amidation, esterification, and coupling reactions. The molecule exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   63.6
  • LogP   1.1618
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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