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CS-W001157 4
Total: USD 88.00

4-Bromo-5-chloro-2-iodoaniline

  • CAS No. 1426566-89-3

  • Cat. No. CS-0463666
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD27920809

*For research and further manufacturing use only, not for direct human use.

4-Bromo-5-chloro-2-iodoaniline|CS-0463666

Structure of 1426566-89-3

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General Information

  • CAS No. 1426566-89-3
  • Cat. No. CS-0463666
  • Purity ≥95%
  • MDL No. MFCD27920809
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrClIN
  • Molecular Weight None
  • Synonym(s) 4-Bromo-5-chloro-2-iodo-phenylamine
  • SMILES C1=C(C(=CC(=C1I)N)Cl)Br

Description

4-Bromo-5-chloro-2-iodoaniline features three halogen substituents positioned for orthogonal reactivity in cross-coupling cascades. This trihalogenated aniline serves as a key intermediate in the synthesis of complex heterocycles and functionalized aryl scaffolds, enabling sequential metal-mediated transformations under mild conditions.

Application

4-Bromo-5-chloro-2-iodoaniline serves as a versatile trihalogenated aniline building block for the synthesis of complex heterocycles and pharmaceutical intermediates. Its orthogonal halogen reactivity enables sequential cross-coupling reactions, facilitating efficient access to substituted biaryls and fused ring systems. The molecule exhibits good bench stability and is compatible with standard palladium-catalyzed coupling protocols, offering predictable regioselectivity in Suzuki, Stille, and Negishi transformations.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   3.2893
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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