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Structure of 142340-15-6
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5-Iodoquinolin-8-amine serves as a pivotal building block in medicinal chemistry, featuring a reactive iodine atom at the 5-position and a primary amine at the 8-position. This dual functionality enables direct coupling reactions in cross-coupling protocols and facilitates conjugation to biomolecules. The quinoline scaffold imparts enhanced metabolic stability and favorable pharmacokinetic properties. This compound is particularly valuable for synthesizing targeted therapeutics and fluorescent probes.
5-Iodoquinolin-8-amine serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to biologically relevant quinoline scaffolds. Its iodide functionality facilitates reliable C–C and C–N bond formation under standard conditions, while the amino group provides orthogonal reactivity for further derivatization. The compound exhibits excellent bench stability and is readily purified by chromatography or recrystallization, making it well-suited for medicinal chemistry campaigns and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: