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CS-W001157 4
Total: USD 88.00

6-Isopropylnicotinic acid hydrochloride

  • CAS No. 1423029-80-4

  • Cat. No. CS-0187222
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Isopropylnicotinic acid hydrochloride|CS-0187222

Structure of 1423029-80-4

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General Information

  • CAS No. 1423029-80-4
  • Cat. No. CS-0187222
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂ClNO₂
  • Molecular Weight 201.65
  • Synonym(s) 6-Isopropylnicotinic Acid Hydrochloric Acid Salt
  • SMILES O=C(O)C1=CN=C(C(C)C)C=C1.[H]Cl

Description

6-Isopropylnicotinic acid hydrochloride features a sterically hindered isopropyl group at the pyridine ring's 6-position, enhancing metabolic stability. This bench-stable salt form improves solubility and handling in synthetic workflows, enabling efficient integration into pharmaceutical intermediates and bioactive molecule scaffolds.

Application

6-Isopropylnicotinic acid hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted nicotinamide derivatives and heterocyclic scaffolds. Its well-defined functional group tolerance facilitates direct amidation and coupling reactions, while the protonated form enhances solubility and stability during purification. The isopropyl substituent provides steric bulk and metabolic stability, making it valuable for optimizing pharmacokinetic profiles in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.325
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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