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CS-W001157 4
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3-(2-((3-((9H-carbazol-4-yl)oxy)-2-hydroxypropyl)amino)ethoxy)-4-methoxyphenol

  • CAS No. 142227-51-8

  • Cat. No. CS-0446069
  • Purity≥98%
  • MDL No.MFCD04039562

*For research and further manufacturing use only, not for direct human use.

3-(2-((3-((9H-carbazol-4-yl)oxy)-2-hydroxypropyl)amino)ethoxy)-4-methoxyphenol|CS-0446069

Structure of 142227-51-8

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General Information

  • CAS No. 142227-51-8
  • Cat. No. CS-0446069
  • Purity ≥98%
  • MDL No. MFCD04039562
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₆N₂O₅
  • Molecular Weight 422.47
  • Synonym(s) 5'-Hydroxyphenyl Carvedilol
  • SMILES COC1=C(C=C(C=C1)O)OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O

Description

A cell-permeable, potent, specific, and nontoxic inhibitor of the DNA repair enzyme, APE1 (human apurinic/apyrimidinic endonuclease; IC50 = ~3 M). Shown to target the APE1 active site and inhibit its 3-phosphodiesterase and 3-phosphatase activities. Exhibits minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentration as high as 100 M. Also shown to potentiate the cytotoxicity of several DNA damaging agents, such as MMS, temozolomide, Zeocin, and H2O2 in HeLa, HT1080, and MDA-MB-231 cells.

Safety Information

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GHS Pictogram :
GHS No : GHS08,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H373-H411
Precautionary Statements : P260-P273-P314-P391-P501

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Computational Chemistry Data

  • TPSA   95.97
  • LogP   3.4436
  • H_Acceptors   6
  • H_Donors   4
  • Rotatable_Bonds   10

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