Mutated EGFR-IN-1

Name: Mutated EGFR-IN-1
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1421372-66-8
Cat. No. CS-3259
Purity≥98%
MDL No.MFCD28167800

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HazMat Fee

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Description

Mutated EGFR-IN-1 is a potent, selective inhibitor targeting oncogenic mutant forms of epidermal growth factor receptor (EGFR), including T790M and L858R variants. This compound exhibits enhanced binding affinity to mutated kinase domains while maintaining minimal activity against wild-type EGFR, enabling precise suppression of aberrant signaling pathways in resistant non-small cell lung cancer models.

Application

Mutated EGFR-IN-1 serves as a selective inhibitor targeting oncogenic mutant forms of the epidermal growth factor receptor, particularly L858R and exon 19 deletion variants. It functions as a potent, ATP-competitive kinase inhibitor with demonstrated utility in preclinical models of non-small cell lung cancer. The compound exhibits favorable stability and solubility profiles, enabling reliable use in cellular assays and biochemical screening workflows.

General Information

CAS No. 1421372-66-8
Cat. No. CS-3259
Purity ≥98%
MDL No. MFCD28167800
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₃₁N₇O
Molecular Weight 445.56
Synonym(s) Osimertinib analog
SMILES NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C

Computational Chemistry Data

TPSA 84.47
LogP 3.9675
H_Acceptors 8
H_Donors 2
Rotatable_Bonds 8

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Mutated EGFR-IN-1

CAS No. 1421372-66-8

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