Mutated EGFR-IN-1

Name: Mutated EGFR-IN-1
Brand: ChemScene
Availability: InStock
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CAS No. 1421372-66-8
Cat. No. CS-3259
Molecule weight445.56
Purity≥98%
MDL No.MFCD28167800

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 1421372-66-8

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General Information

CAS No. 1421372-66-8
Cat. No. CS-3259
Purity ≥98%
MDL No. MFCD28167800
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₃₁N₇O
Molecular Weight 445.56
Synonym(s) Osimertinib analog
SMILES NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C

Description

Mutated EGFR-IN-1 is a potent, selective inhibitor targeting oncogenic mutant forms of epidermal growth factor receptor (EGFR), including T790M and L858R variants. This compound exhibits enhanced binding affinity to mutated kinase domains while maintaining minimal activity against wild-type EGFR, enabling precise suppression of aberrant signaling pathways in resistant non-small cell lung cancer models.

Application

Mutated EGFR-IN-1 serves as a selective inhibitor targeting oncogenic mutant forms of the epidermal growth factor receptor, particularly L858R and exon 19 deletion variants. It functions as a potent, ATP-competitive kinase inhibitor with demonstrated utility in preclinical models of non-small cell lung cancer. The compound exhibits favorable stability and solubility profiles, enabling reliable use in cellular assays and biochemical screening workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 84.47
LogP 3.9675
H_Acceptors 8
H_Donors 2
Rotatable_Bonds 8

Key Words

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Mutated EGFR-IN-1

CAS No. 1421372-66-8

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