6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride

Name: 6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride
Brand: ChemScene
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CAS No. 1420294-83-2
Cat. No. CS-0133674
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride|CS-0133674

Structure of 1420294-83-2

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General Information

CAS No. 1420294-83-2
Cat. No. CS-0133674
Purity ≥98%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₀ClF₂N
Molecular Weight 169.60
Synonym(s) None
SMILES FC(C1)(F)CC21CNC2.[H]Cl

Description

6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride is a rigid, electron-deficient spirocyclic amine featuring two fluorine atoms at the 6-position, enhancing metabolic stability and modulating lipophilicity. This bench-stable salt form improves solubility and handling in synthetic workflows, enabling efficient incorporation into bioactive molecules.

Application

6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride serves as a conformationally constrained, fluorinated heterocyclic building block for medicinal chemistry applications. Its spirocyclic scaffold imparts rigidity and metabolic stability, while the difluoro substitution enhances membrane permeability and modulates pKa. The hydrochloride salt ensures excellent solubility and bench stability, enabling straightforward handling in standard coupling and functionalization reactions. Functions effectively in the synthesis of bioactive molecules requiring defined stereochemistry and enhanced pharmacokinetic properties.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 12.03
LogP 1.4269
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride

CAS No. 1420294-83-2

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