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CS-W001157 4
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Fmoc-D-Orn(Dde)-OH

  • CAS No. 1419640-31-5

  • Cat. No. CS-0173477
  • Purity≥98%
  • MDL No.MFCD02094127

*For research and further manufacturing use only, not for direct human use.

Fmoc-D-Orn(Dde)-OH|CS-0173477

Structure of 1419640-31-5

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General Information

  • CAS No. 1419640-31-5
  • Cat. No. CS-0173477
  • Purity ≥98%
  • MDL No. MFCD02094127
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₀H₃₄N₂O₆
  • Molecular Weight 518.60
  • Synonym(s) N5-[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]ornithine
  • SMILES C/C(NCCC[C@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=C4C(CC(C)(CC/4=O)C)=O

Description

Fmoc-D-Orn(Dde)-OH is a protected amino acid derivative designed for solid-phase peptide synthesis. The Fmoc group enables orthogonal deprotection, while the Dde moiety on the side chain provides selective removal under mild conditions. This combination facilitates efficient incorporation of D-ornithine into complex sequences with minimal epimerization and high fidelity.

Application

Fmoc-D-Orn(Dde)-OH serves as a key building block in solid-phase peptide synthesis, enabling the incorporation of D-ornithine with orthogonal protection. The Fmoc group allows for mild deprotection under basic conditions, while the Dde (1,3-dimethylbutyl) side chain protection is selectively removed via hydrazinolysis, facilitating sequential coupling and site-specific modifications. Its stability during handling and compatibility with standard peptide synthesis protocols make it ideal for constructing complex peptidomimetics and cyclic peptides.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   121.8
  • LogP   4.5803
  • H_Acceptors   6
  • H_Donors   3
  • Rotatable_Bonds   9

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