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CS-W001157 4
Total: USD 88.00

PCPA methyl ester hydrochloride

  • CAS No. 14173-40-1

  • Cat. No. CS-0021369
  • Molecule weightNone
  • Purity≥98%
  • MDL No.MFCD00012530

*For research and further manufacturing use only, not for direct human use.

PCPA methyl ester hydrochloride|CS-0021369

Structure of 14173-40-1

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General Information

  • CAS No. 14173-40-1
  • Cat. No. CS-0021369
  • Purity ≥98%
  • MDL No. MFCD00012530
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃Cl₂NO₂
  • Molecular Weight None
  • Synonym(s) 4-Chloro-DL-phenylalanine methyl ester (hydrochloride)
  • SMILES NC(CC1=CC=C(Cl)C=C1)C(OC)=O.Cl

Description

Inhibiting tryptophan hydroxylase activity, 4-Chloro-DL-phenylalanine methyl ester hydrochloride (CAS 14173-40-1) suppresses central serotonin synthesis by penetrating the blood-brain barrier and depleting neuronal 5-HT pools.

Application

4-Chloro-DL-phenylalanine methyl ester hydrochloride (CAS 14173-40-1) induces targeted 5-HT depletion in rat models by disrupting serotonin synthesis through competitive inhibition of aromatic amino acid decarboxylase. This enables precise neurochemical studies. Researchers use it to investigate mood regulation and behavioral responses linked to serotonergic pathways.

Synthesis

  • Route1
    • null|null
      182249-59-8
    • ~%
    • In-stock
      PCPA methyl ester hydrochloride|CS-0021369
      14173-40-1

    References

    • Journal of Organic Chemistry, , vol. 61, # 19 p. 6581 - 6586
  • Route2
    • null|null
      67-56-1
    • In-stock
      4-Chloro-L-phenylalanine|CS-0030550
      14173-39-8
    • ~65%
    • In-stock
      PCPA methyl ester hydrochloride|CS-0021369
      14173-40-1

    References

    • Li, Xun; Wang, Junli; Zhang, Lei; Xu, Wenfang Archiv der Pharmazie, 2011 , vol. 344, # 8 p. 494 - 504
  • Route3
    • null|null
      159750-04-6
    • ~%
    • In-stock
      PCPA methyl ester hydrochloride|CS-0021369
      14173-40-1

    References

    • Journal of Organic Chemistry, , vol. 61, # 19 p. 6581 - 6586

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   1.8046
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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