(R)-4-(Tert-Butoxycarbonyl)-6,6-dimethylmorpholine-2-carboxylic acid

Name: (R)-4-(Tert-Butoxycarbonyl)-6,6-dimethylmorpholine-2-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 1416445-02-7
Cat. No. CS-0040639
Purity≥95%
MDL No.MFCD22690355

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-4-(Tert-Butoxycarbonyl)-6,6-dimethylmorpholine-2-carboxylic acid|CS-0040639

Structure of 1416445-02-7

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General Information

CAS No. 1416445-02-7
Cat. No. CS-0040639
Purity ≥95%
MDL No. MFCD22690355
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₁NO₅
Molecular Weight 259.30
Synonym(s) None
SMILES O=C([C@H]1CN(C(OC(C)(C)C)=O)CC(C)(C)O1)O

Description

(R)-4-(Tert-Butoxycarbonyl)-6,6-dimethylmorpholine-2-carboxylic acid is a chiral, bench-stable building block featuring a sterically hindered morpholine core. The tert-butoxycarbonyl group enables selective protection of the amine, while the dimethyl substitution enhances stability and modulates reactivity. This derivative facilitates efficient incorporation into complex peptide architectures and bioactive molecule synthesis under standard conditions.

Application

(R)-4-(Tert-Butoxycarbonyl)-6,6-dimethylmorpholine-2-carboxylic acid serves as a stereochemically defined building block for the synthesis of bioactive heterocycles and peptide conjugates. The Boc-protected amine and carboxylic acid functionalities enable orthogonal derivatization, while the rigid, sterically hindered morpholine core enhances metabolic stability. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient incorporation into complex molecular architectures.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 76.07
LogP 1.4855
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-4-(Tert-Butoxycarbonyl)-6,6-dimethylmorpholine-2-carboxylic acid

CAS No. 1416445-02-7

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