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CS-W001157 4
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(R)-4-(Tert-Butoxycarbonyl)-6,6-dimethylmorpholine-2-carboxylic acid

  • CAS No. 1416445-02-7

  • Cat. No. CS-0040639
  • Molecule weight259.30
  • Purity≥95%
  • MDL No.MFCD22690355

*For research and further manufacturing use only, not for direct human use.

(R)-4-(Tert-Butoxycarbonyl)-6,6-dimethylmorpholine-2-carboxylic acid|CS-0040639

Structure of 1416445-02-7

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General Information

  • CAS No. 1416445-02-7
  • Cat. No. CS-0040639
  • Purity ≥95%
  • MDL No. MFCD22690355
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₅
  • Molecular Weight 259.30
  • Synonym(s) None
  • SMILES O=C([C@H]1CN(C(OC(C)(C)C)=O)CC(C)(C)O1)O

Description

(R)-4-(Tert-Butoxycarbonyl)-6,6-dimethylmorpholine-2-carboxylic acid is a chiral, bench-stable building block featuring a sterically hindered morpholine core. The tert-butoxycarbonyl group enables selective protection of the amine, while the dimethyl substitution enhances stability and modulates reactivity. This derivative facilitates efficient incorporation into complex peptide architectures and bioactive molecule synthesis under standard conditions.

Application

(R)-4-(Tert-Butoxycarbonyl)-6,6-dimethylmorpholine-2-carboxylic acid serves as a stereochemically defined building block for the synthesis of bioactive heterocycles and peptide conjugates. The Boc-protected amine and carboxylic acid functionalities enable orthogonal derivatization, while the rigid, sterically hindered morpholine core enhances metabolic stability. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient incorporation into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   76.07
  • LogP   1.4855
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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