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CS-W001157 4
Total: USD 88.00

(4-Amino-3-(trifluoromethyl)phenyl)methanol

  • CAS No. 1416372-95-6

  • Cat. No. CS-0378944
  • Purity≥97%
  • MDL No.MFCD21603964

*For research and further manufacturing use only, not for direct human use.

(4-Amino-3-(trifluoromethyl)phenyl)methanol|CS-0378944

Structure of 1416372-95-6

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General Information

  • CAS No. 1416372-95-6
  • Cat. No. CS-0378944
  • Purity ≥97%
  • MDL No. MFCD21603964
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₃NO
  • Molecular Weight None
  • Synonym(s) None
  • SMILES OCC1=CC=C(N)C(C(F)(F)F)=C1

Description

This bench-stable arylmethanol features a para-amino group flanked by a trifluoromethyl substituent, delivering enhanced electron density and solubility in polar organic solvents. The functional handle enables direct coupling in amide formation or reductive amination workflows, streamlining access to complex pharmaceutical intermediates.

Application

(4-Amino-3-(trifluoromethyl)phenyl)methanol serves as a versatile building block in medicinal chemistry, enabling the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its amino and hydroxymethyl groups offer orthogonal reactivity for coupling, derivatization, and protection strategies. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the molecule exhibits good bench stability and facilitates straightforward purification—ideal for iterative synthetic workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.7799
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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