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CS-W001157 4
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Pyrrolidine-1-sulfonyl fluoride

  • CAS No. 141577-92-6

  • Cat. No. CS-0748297
  • Molecule weight153.18
  • Purity≥98%
  • MDL No.MFCD21602075

*For research and further manufacturing use only, not for direct human use.

Pyrrolidine-1-sulfonyl fluoride|CS-0748297

Structure of 141577-92-6

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General Information

  • CAS No. 141577-92-6
  • Cat. No. CS-0748297
  • Purity ≥98%
  • MDL No. MFCD21602075
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈FNO₂S
  • Molecular Weight 153.18
  • Synonym(s) None
  • SMILES FS(=O)(=O)N1CCCC1

Description

Pyrrolidine-1-sulfonyl fluoride is a bench-stable fluorosulfonyl reagent featuring a cyclic amine scaffold that enables selective sulfonation of nucleophiles. This electrophilic fluorosulfonyl group integrates readily into bioactive molecules, offering enhanced metabolic stability and improved solubility in medicinal chemistry applications.

Application

Pyrrolidine-1-sulfonyl fluoride serves as a versatile electrophilic sulfonylating agent, enabling efficient introduction of sulfonamide groups under mild conditions. Its high reactivity with nucleophiles—particularly amines and alcohols—facilitates rapid access to sulfonamide derivatives, commonly employed in medicinal chemistry scaffolds. The compound exhibits bench stability, ease of handling, and compatibility with diverse functional groups, making it ideal for modular synthesis workflows and late-stage functionalization.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.38
  • LogP   0.2965
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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