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CS-W001157 4
Total: USD 88.00

4-Azaspiro[2.4]heptane hydrochloride

  • CAS No. 1414885-17-8

  • Cat. No. CS-0183849
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Azaspiro[2.4]heptane hydrochloride|CS-0183849

Structure of 1414885-17-8

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Description

4-Azaspiro[2.4]heptane hydrochloride is a conformationally constrained heterocyclic scaffold featuring a nitrogen atom embedded within a spirocyclic framework. This rigid, bench-stable structure delivers enhanced metabolic stability and targeted bioavailability. The hydrochloride salt form improves solubility and handling in aqueous media, enabling seamless integration into medicinal chemistry campaigns targeting CNS-penetrant therapeutics and kinase modulators.

Application

4-Azaspiro[2.4]heptane hydrochloride serves as a rigid, conformationally constrained heterocyclic scaffold ideal for medicinal chemistry exploration. Its spirocyclic structure imparts distinct three-dimensional geometry, enhancing target selectivity in drug discovery. The protonated nitrogen enables salt formation for improved solubility and stability, while tolerating a range of functional groups during downstream derivatization. Functions effectively in standard coupling and alkylation protocols, facilitating rapid access to diverse analogs.

General Information

  • CAS No. 1414885-17-8
  • Cat. No. CS-0183849
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClN
  • Molecular Weight 133.62
  • Synonym(s) None
  • SMILES [H]Cl.C1CC12NCCC2

Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.3242
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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