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CS-W001157 4
Total: USD 88.00

4-Azaspiro[2.4]heptane hydrochloride

  • CAS No. 1414885-17-8

  • Cat. No. CS-0183849
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Azaspiro[2.4]heptane hydrochloride|CS-0183849

Structure of 1414885-17-8

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General Information

  • CAS No. 1414885-17-8
  • Cat. No. CS-0183849
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClN
  • Molecular Weight 133.62
  • Synonym(s) None
  • SMILES [H]Cl.C1CC12NCCC2

Description

4-Azaspiro[2.4]heptane hydrochloride is a conformationally constrained heterocyclic scaffold featuring a nitrogen atom embedded within a spirocyclic framework. This rigid, bench-stable structure delivers enhanced metabolic stability and targeted bioavailability. The hydrochloride salt form improves solubility and handling in aqueous media, enabling seamless integration into medicinal chemistry campaigns targeting CNS-penetrant therapeutics and kinase modulators.

Application

4-Azaspiro[2.4]heptane hydrochloride serves as a rigid, conformationally constrained heterocyclic scaffold ideal for medicinal chemistry exploration. Its spirocyclic structure imparts distinct three-dimensional geometry, enhancing target selectivity in drug discovery. The protonated nitrogen enables salt formation for improved solubility and stability, while tolerating a range of functional groups during downstream derivatization. Functions effectively in standard coupling and alkylation protocols, facilitating rapid access to diverse analogs.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.3242
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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