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Structure of 1414885-17-8
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4-Azaspiro[2.4]heptane hydrochloride is a conformationally constrained heterocyclic scaffold featuring a nitrogen atom embedded within a spirocyclic framework. This rigid, bench-stable structure delivers enhanced metabolic stability and targeted bioavailability. The hydrochloride salt form improves solubility and handling in aqueous media, enabling seamless integration into medicinal chemistry campaigns targeting CNS-penetrant therapeutics and kinase modulators.
4-Azaspiro[2.4]heptane hydrochloride serves as a rigid, conformationally constrained heterocyclic scaffold ideal for medicinal chemistry exploration. Its spirocyclic structure imparts distinct three-dimensional geometry, enhancing target selectivity in drug discovery. The protonated nitrogen enables salt formation for improved solubility and stability, while tolerating a range of functional groups during downstream derivatization. Functions effectively in standard coupling and alkylation protocols, facilitating rapid access to diverse analogs.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: