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CS-W001157 4
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1-(Dimethylamino)-2-methylpropan-2-ol

  • CAS No. 14123-48-9

  • Cat. No. CS-0147115
  • Purity≥98%
  • MDL No.MFCD11934288

*For research and further manufacturing use only, not for direct human use.

1-(Dimethylamino)-2-methylpropan-2-ol|CS-0147115

Structure of 14123-48-9

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General Information

  • CAS No. 14123-48-9
  • Cat. No. CS-0147115
  • Purity ≥98%
  • MDL No. MFCD11934288
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₅NO
  • Molecular Weight 117.19
  • Synonym(s) 2-(Dimethylaminomethyl)-2-propanol
  • SMILES CC(O)(CN(C)C)C

Description

This tertiary alcohol features a dimethylamino group that enhances solubility and reactivity in polar media, while the methylated quaternary carbon center imparts steric stability. It functions as a nucleophilic amine surrogate in synthetic transformations, particularly in catalytic systems requiring hindered, moisture-tolerant amines.

Application

1-(Dimethylamino)-2-methylpropan-2-ol serves as a stable, bench-ready tertiary alcohol with enhanced solubility in polar organic solvents. It functions as a versatile building block in synthetic routes requiring sterically hindered alcohols, enabling efficient protection strategies and facilitating nucleophilic substitution reactions. Its dimethylamino group enhances basicity and reactivity in deprotonation or condensation processes, while the tert-butyl-like framework provides structural rigidity and resistance to oxidation. This compound is particularly useful in the synthesis of pharmaceutical intermediates and complex heterocyclic scaffolds due to its predictable reactivity and ease of purification.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07,GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H318-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P332+P313-P362+P364-P370+P378-P403+P233-P403+P235-P405-P501

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   0.3189
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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