Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Methyl-1,2,3,4-tetrahydroisoquinolin-7-amine

  • CAS No. 14097-40-6

  • Cat. No. CS-0051887
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methyl-1,2,3,4-tetrahydroisoquinolin-7-amine|CS-0051887

Structure of 14097-40-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 14097-40-6
  • Cat. No. CS-0051887
  • Purity ≥96%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄N₂
  • Molecular Weight 162.23
  • Synonym(s) 1,2,3,4-TETRAHYDRO-2-METHYL-7-ISOQUINOLINAMINE
  • SMILES CN1CCC2=CC=C(N)C=C2C1

Description

2-Methyl-1,2,3,4-tetrahydroisoquinolin-7-amine features a sterically hindered tetrahydroisoquinoline core with a primary amine at the 7-position, enabling direct functionalization in synthetic routes. This scaffold integrates readily into bioactive molecules, offering enhanced metabolic stability and favorable solubility for medicinal chemistry applications.

Application

2-Methyl-1,2,3,4-tetrahydroisoquinolin-7-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive alkaloids and heterocyclic scaffolds. Its pendant amine group facilitates facile functionalization, while the tetrahydroisoquinoline core exhibits favorable stability and solubility for solution-phase synthesis. The molecule functions effectively in reductive amination, coupling reactions, and cyclization protocols commonly employed in API development.

Synthesis

  • Route1
    • 2-Methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline|CS-0469708
      14097-35-9
    • ~98%
    • In-stock
      2-Methyl-1,2,3,4-tetrahydroisoquinolin-7-amine|CS-0051887
      14097-40-6

    References

    • Chan, Wai N.; Hadley, Michael S.; Harling, John D.; Herdon, Hugh J.; Orlek, Barry S.; Riley, Graham J.; Stead, Rachel E. A.; Stean, Tania O.; Thompson, Mervyn; Upton, Neil; Ward, Robert W. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2085 - 2094
  • Route2

    References

    • BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG Patent: WO2007/48802 A1, 2007 ; Location in patent: Page/Page column 93 ;
  • Route3

    References

    • Chan, Wai N.; Hadley, Michael S.; Harling, John D.; Herdon, Hugh J.; Orlek, Barry S.; Riley, Graham J.; Stead, Rachel E. A.; Stean, Tania O.; Thompson, Mervyn; Upton, Neil; Ward, Robert W. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2085 - 2094

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   29.26
  • LogP   1.2567
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 14097-40-6 sigma14097-40-6 manufacturer14097-40-6 price14097-40-6 structure14097-40-6 SDSbuy 14097-40-614097-40-6 supplier14097-40-6 uses14097-40-6 molecular weightprice of 14097-40-614097-40-6 chemical name formula of 14097-40-6
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label