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CS-W001157 4
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8-Oxa-2-azaspiro[4.5]decane hydrochloride

  • CAS No. 1408074-48-5

  • Cat. No. CS-0049940
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

8-Oxa-2-azaspiro[4.5]decane hydrochloride|CS-0049940

Structure of 1408074-48-5

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General Information

  • CAS No. 1408074-48-5
  • Cat. No. CS-0049940
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆ClNO
  • Molecular Weight 177.67
  • Synonym(s) 8-Oxa-2-aza-spiro[4.5]decane hydrochloride - X10439
  • SMILES Cl.C1CC2(CN1)CCOCC2

Description

8-Oxa-2-azaspiro[4.5]decane hydrochloride is a rigid, bicyclic heterocycle featuring a spiro-linked oxygen and nitrogen atom, delivering enhanced conformational stability. This scaffold integrates a basic amine moiety with favorable solubility and metabolic resilience, enabling efficient incorporation into bioactive molecule design.

Application

8-Oxa-2-azaspiro[4.5]decane hydrochloride serves as a versatile spirocyclic scaffold in medicinal chemistry, enabling the construction of constrained heterocyclic systems with defined stereochemistry. Its stable, crystalline form facilitates handling and purification, while the embedded amine and ether functionalities offer orthogonal reactivity for downstream functionalization. This compound functions as a key building block in the synthesis of bioactive molecules, particularly those requiring rigid, three-dimensional architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   1.1983
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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