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CS-W001157 4
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(S)-(4,4-Difluoro-1-methylpyrrolidin-2-yl)methanol

  • CAS No. 1408057-44-2

  • Cat. No. CS-0053060
  • Molecule weight151.15
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-(4,4-Difluoro-1-methylpyrrolidin-2-yl)methanol|CS-0053060

Structure of 1408057-44-2

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General Information

  • CAS No. 1408057-44-2
  • Cat. No. CS-0053060
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁F₂NO
  • Molecular Weight 151.15
  • Synonym(s) [(2S)-4,4-difluoro-1-methylpyrrolidin-2-yl]methanol
  • SMILES CN1CC(F)(F)C[C@H]1CO

Description

(S)-(4,4-Difluoro-1-methylpyrrolidin-2-yl)methanol is a chiral building block featuring a sterically constrained pyrrolidine core with dual fluorine atoms at the C4 position. The methanol functionality enables direct derivatization, while the (S)-configuration ensures high stereocontrol in asymmetric synthesis. This bench-stable, moisture-tolerant reagent integrates efficiently into complex molecular architectures.

Application

(S)-(4,4-Difluoro-1-methylpyrrolidin-2-yl)methanol serves as a valuable chiral building block in medicinal chemistry, enabling efficient access to fluorinated pyrrolidine scaffolds prevalent in bioactive molecules. Its bench-stable nature and compatibility with standard coupling and functionalization protocols facilitate streamlined synthesis of drug candidates. The difluoro substitution enhances metabolic stability, while the hydroxymethyl group provides a versatile handle for further derivatization.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   0.3181
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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