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Structure of 1404196-37-7
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tert-Butyl 2-fluoro-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate features a rigid, electron-deficient bicyclic core with a fluorinated C2 position and a ketone at C3, enabling selective functionalization in complex molecular architectures. The tert-butyl ester group provides stability and facilitates downstream deprotection under mild acidic conditions. This scaffold serves as a key intermediate in the synthesis of bioactive nitrogen-containing heterocycles.
tert-Butyl 2-fluoro-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate serves as a versatile, bench-stable building block for the synthesis of fluorinated nitrogen heterocycles. The molecule enables efficient access to complex bicyclic scaffolds through selective reductions, nucleophilic additions, and functional group interconversions. Its 3-oxo and 2-fluoro motifs provide orthogonal reactivity, facilitating downstream derivatization in medicinal chemistry campaigns. The tert-butyl ester offers ease of purification and compatibility with standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H314-H318
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: