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Structure of 1403993-56-5
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3-(Difluoromethoxy)azetidine is a strained, electron-deficient azetidine derivative featuring a difluoromethoxy group that enhances metabolic stability and modulates lipophilicity. This scaffold integrates readily into bioactive molecules, offering improved membrane permeability and resistance to enzymatic degradation in medicinal chemistry applications.
3-(Difluoromethoxy)azetidine serves as a valuable building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethoxy group within bioactive scaffolds. Its azetidine core offers enhanced solubility and conformational rigidity, while the difluoromethoxy substituent provides favorable lipophilicity and electron-withdrawing character. The compound exhibits good bench stability and compatibility with standard coupling reactions, facilitating efficient incorporation into diverse heterocyclic systems and API candidates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: