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CS-W001157 4
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Ethyl 2-(N-Methoxy-N-methylamino)-2-oxoacetate

  • CAS No. 139507-52-1

  • Cat. No. CS-0151904
  • Purity≥98%
  • MDL No.MFCD11975566

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(N-Methoxy-N-methylamino)-2-oxoacetate|CS-0151904

Structure of 139507-52-1

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General Information

  • CAS No. 139507-52-1
  • Cat. No. CS-0151904
  • Purity ≥98%
  • MDL No. MFCD11975566
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO₄
  • Molecular Weight 161.16
  • Synonym(s) Ethyl 2-(N-Methoxy-N-methylamino)
  • SMILES CCOC(=O)C(=O)N(C)OC

Description

Ethyl 2-(N-Methoxy-N-methylamino)-2-oxoacetate is a bench-stable, moisture-tolerant reagent featuring a masked amine functionality that enables direct incorporation into complex molecular architectures. This electrophilic ester integrates readily in nucleophilic substitution cascades, delivering nitrogen-containing motifs with high regiocontrol under mild conditions.

Application

Ethyl 2-(N-methoxy-N-methylamino)-2-oxoacetate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to β-amino carbonyl scaffolds. Its activated ester functionality facilitates nucleophilic addition reactions, while the N-methoxy-N-methylamino group enhances stability and modulates reactivity. This compound functions as a key intermediate in the construction of heterocyclic systems and peptide-like motifs, offering excellent functional group tolerance and ease of purification under standard bench conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS08,GHS09
Signal Word : Danger
UN#: 3082
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H372-H411
Precautionary Statements : P260-P264-P273-P391-P501

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Computational Chemistry Data

  • TPSA   55.84
  • LogP   -0.4307
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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