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CS-W001157 4
Total: USD 88.00

{3-[(tert-Butyldimethylsilyl)oxy]cyclobutyl}methanol

  • CAS No. 1394119-83-5

  • Cat. No. CS-0052957
  • Purity≥98%
  • MDL No.MFCD23106334

*For research and further manufacturing use only, not for direct human use.

{3-[(tert-Butyldimethylsilyl)oxy]cyclobutyl}methanol|CS-0052957

Structure of 1394119-83-5

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General Information

  • CAS No. 1394119-83-5
  • Cat. No. CS-0052957
  • Purity ≥98%
  • MDL No. MFCD23106334
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₄O₂Si
  • Molecular Weight 216.40
  • Synonym(s) None
  • SMILES OCC1CC(O[Si](C)(C)C(C)(C)C)C1

Description

This silyl-protected cyclobutanol derivative features a tert-butyldimethylsilyl ether group that confers exceptional stability and moisture tolerance. The pendant hydroxymethyl functionality enables selective functionalization or conjugation, while the rigid cyclobutane scaffold provides defined stereochemical control. Ideal for complex molecule synthesis under standard bench conditions.

Application

{3-[(tert-Butyldimethylsilyl)oxy]cyclobutyl}methanol serves as a versatile silyl-protected alcohol intermediate, enabling selective functionalization in complex molecule synthesis. The tert-butyldimethylsilyl (TBS) group provides excellent bench stability and orthogonal protection, facilitating purification and compatibility with diverse reaction conditions. It functions as a key building block for cyclobutane-containing scaffolds, particularly in medicinal chemistry and natural product synthesis, where controlled introduction of hydroxyl equivalents is required.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   2.7791
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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