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CS-W001157 4
Total: USD 88.00

2-Bromoquinolin-8-ol

  • CAS No. 139399-61-4

  • Cat. No. CS-0041975
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromoquinolin-8-ol|CS-0041975

Structure of 139399-61-4

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General Information

  • CAS No. 139399-61-4
  • Cat. No. CS-0041975
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆BrNO
  • Molecular Weight 224.05
  • Synonym(s) 2-bromo-8-quinolinol
  • SMILES OC1=C2N=C(Br)C=CC2=CC=C1

Description

2-Bromoquinolin-8-ol features a bromine atom at the C2 position and a hydroxyl group at C8, creating a unique scaffold for transition-metal-catalyzed cross-coupling reactions. This electron-deficient heterocycle integrates readily into complex molecular architectures under standard conditions.

Application

2-Bromoquinolin-8-ol serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality and phenolic hydroxyl group. The molecule exhibits good bench stability and facilitates efficient derivatization in medicinal chemistry workflows, particularly for constructing quinoline-based scaffolds found in kinase inhibitors and antimalarial agents. Its compatibility with standard coupling conditions supports scalable synthesis and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.7029
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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