5-Chloro-4-fluoropyridin-2-amine

Name: 5-Chloro-4-fluoropyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1393574-54-3
Cat. No. CS-0103373
Purity≥95%
MDL No.MFCD22547000

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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*For research and further manufacturing use only, not for direct human use.

5-Chloro-4-fluoropyridin-2-amine|CS-0103373

Structure of 1393574-54-3

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Description

5-Chloro-4-fluoropyridin-2-amine features a strategically positioned chloro and fluoro substituent on the pyridine ring, enabling selective coupling reactions in medicinal chemistry. The electron-deficient heterocycle integrates readily into kinase inhibitors and bioactive scaffolds, offering enhanced metabolic stability and favorable binding affinity. This bench-stable reagent supports efficient transition metal-catalyzed transformations under standard conditions.

Application

5-Chloro-4-fluoropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its orthogonal reactivity—where the amine group facilitates nucleophilic substitution and the halogens support palladium-catalyzed coupling—enables modular synthesis of complex APIs. Bench-stable and readily purified, it functions effectively in standard cross-coupling, cyclization, and derivatization workflows common in drug discovery.

General Information

CAS No. 1393574-54-3
Cat. No. CS-0103373
Purity ≥95%
MDL No. MFCD22547000
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClFN₂
Molecular Weight None
Synonym(s) 5-Chloro-4-fluoro-pyridin-2-ylamine
SMILES NC1=NC=C(C(F)=C1)Cl

Computational Chemistry Data

TPSA 38.91
LogP 1.4563
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Chloro-4-fluoropyridin-2-amine

CAS No. 1393574-54-3

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