1-Cyclopropyl-1H-pyrazole-5-carboxylic acid

Name: 1-Cyclopropyl-1H-pyrazole-5-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1393532-43-8
Cat. No. CS-0052577
Purity≥98%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1-Cyclopropyl-1H-pyrazole-5-carboxylic acid|CS-0052577

Structure of 1393532-43-8

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General Information

CAS No. 1393532-43-8
Cat. No. CS-0052577
Purity ≥98%
MDL No. None
Storage 4°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈N₂O₂
Molecular Weight 152.15
Synonym(s) None
SMILES OC(=O)C1=CC=NN1C1CC1

Description

1-Cyclopropyl-1H-pyrazole-5-carboxylic acid features a rigid cyclopropyl group attached to the pyrazole core, enhancing metabolic stability and lipophilicity. The carboxylic acid moiety enables direct conjugation or derivatization in medicinal chemistry campaigns. This scaffold integrates well into bioactive molecules requiring balanced solubility and membrane permeability.

Application

1-Cyclopropyl-1H-pyrazole-5-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its pyrazole core provides robust stability and orthogonal reactivity, while the carboxylic acid functionality enables direct coupling or derivatization in standard amide formation, esterification, and macrocyclization protocols. The cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, offering favorable physicochemical properties for drug-like scaffolds. This compound demonstrates excellent bench stability and compatibility with common purification methods, facilitating efficient integration into multi-step synthetic sequences.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 55.12
LogP 0.9162
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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1-Cyclopropyl-1H-pyrazole-5-carboxylic acid

CAS No. 1393532-43-8

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