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CS-W001157 4
Total: USD 88.00

Benzyldimethyltetradecylammonium chloride

  • CAS No. 139-08-2

  • Cat. No. CS-W011803
  • Purity≥98%
  • MDL No.MFCD00011771
  • AREC Toxic Substance

*For research and further manufacturing use only, not for direct human use.

Benzyldimethyltetradecylammonium chloride|CS-W011803

Structure of 139-08-2

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General Information

  • CAS No. 139-08-2
  • Cat. No. CS-W011803
  • Purity ≥98%
  • MDL No. MFCD00011771
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₄₂ClN
  • Molecular Weight 368.05
  • Synonym(s) None
  • SMILES [Cl-].CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1

Description

A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 M), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 M), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.

Synthesis

  • Route1

    References

    • EP1505058 A1, ; Page/Page column 4 ;
  • Route2
    • null|null
      112-75-4
    • null|null
      100-44-7
    • ~%
    • In-stock
      Benzyldimethyltetradecylammonium chloride|CS-W011803
      139-08-2

    References

    • Revue Roumaine de Chimie, , vol. 46, # 1 p. 49 - 53

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS09
Signal Word : Danger
UN#: 2923
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312-H314-H410
Precautionary Statements : P260-P264-P270-P273-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P362+P364-P363-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.9681
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   15

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