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(R)-Hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one hydrochloride

  • CAS No. 1383427-89-1

  • Cat. No. CS-0053103
  • Molecule weight192.64
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-Hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one hydrochloride|CS-0053103

Structure of 1383427-89-1

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General Information

  • CAS No. 1383427-89-1
  • Cat. No. CS-0053103
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃ClN₂O₂
  • Molecular Weight 192.64
  • Synonym(s) (9aR)-octahydropiperazino[2,1-c]morpholin-4-one hydrochloride
  • SMILES Cl.O=C1COC[C@H]2CNCCN12

Description

(R)-Hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one hydrochloride is a chiral heterocyclic scaffold featuring a fused oxazine and piperazine ring system. This bench-stable, moisture-tolerant compound integrates a defined stereochemical center at the C4 position, enabling precise control in asymmetric synthesis. The hydrochloride salt enhances solubility and handling for use in medicinal chemistry campaigns targeting CNS-directed therapeutics and kinase inhibitors.

Application

(R)-Hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one hydrochloride serves as a versatile chiral building block for the synthesis of bioactive heterocycles. Its rigid, polycyclic structure provides defined stereochemistry and enhanced metabolic stability, enabling efficient incorporation into peptidomimetics and kinase inhibitor scaffolds. The hydrochloride salt ensures excellent bench stability and facilitates purification via standard ion-exchange chromatography.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   -0.7612
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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