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CS-W001157 4
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2-(7-Methoxynaphthalen-1-yl)ethan-1-amine

  • CAS No. 138113-09-4

  • Cat. No. CS-0445795
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(7-Methoxynaphthalen-1-yl)ethan-1-amine|CS-0445795

Structure of 138113-09-4

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General Information

  • CAS No. 138113-09-4
  • Cat. No. CS-0445795
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₅NO
  • Molecular Weight 201.26
  • Synonym(s) 7-methoxy-1-Naphthaleneethanamine
  • SMILES COC1=CC2=C(C=CC=C2CCN)C=C1

Description

This 2-(7-methoxynaphthalen-1-yl)ethan-1-amine features a naphthalene core with a methoxy group at the 7-position, providing enhanced solubility and electronic modulation. The pendant ethylamine handle enables facile conjugation in synthetic transformations. Bench-stable and moisture-tolerant, it serves as a key building block for fluorescent probes and bioactive molecule scaffolds.

Application

2-(7-Methoxynaphthalen-1-yl)ethan-1-amine serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its naphthalene core provides enhanced π-stacking potential, while the pendant amine enables facile derivatization via amidation, alkylation, or reductive amination. The methoxy group enhances solubility and modulates electronic properties, offering favorable handling and purification characteristics in standard organic workflows.

Synthesis

  • Route1

    References

    • Tianjin Taipu Pharmaceutical Science and Technology Development Co., Ltd. Patent: EP2474522 A1, 2012 ; Location in patent: Page/Page column 8-9 ;
  • Route2
    • null|null
      1415243-95-6
    • ~78%
    • In-stock
      2-(7-Methoxynaphthalen-1-yl)ethan-1-amine|CS-0445795
      138113-09-4

    References

    • Kandagatla, Bhaskar; Raju, Vetukuri Venkata Naga Kali Vara Prasada; Reddy, Ganta Madhusudhan; Rao, Sirigiri Chandrakanth; Iqbal, Javed; Bandichhor, Rakeshwar; Oruganti, Srinivas Tetrahedron Letters, 2012 , vol. 53, # 52 p. 7125 - 7127
  • Route3
    • null|null
      1207480-89-4
    • ~77%
    • In-stock
      2-(7-Methoxynaphthalen-1-yl)ethan-1-amine|CS-0445795
      138113-09-4

    References

    • LES LABORATOIRES SERVIER Patent: US2010/36163 A1, 2010 ; Location in patent: Page/Page column 2 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H319
Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.3496
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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