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CS-W001157 4
Total: USD 88.00

Thiol-PEG2-acid

  • CAS No. 1379649-73-6

  • Cat. No. CS-0148621
  • Purity≥95%
  • MDL No.MFCD24503001
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Thiol-PEG2-acid|CS-0148621

Structure of 1379649-73-6

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Description

Thiol-PEG2-acid features a short, hydrophilic PEG spacer linking a reactive thiol group to a terminal carboxylic acid. This dual-functional design enables site-specific conjugation via thiol-maleimide or amine coupling, while the acid moiety facilitates further bioconjugation or surface immobilization. The molecule exhibits excellent solubility in aqueous and organic solvents, with enhanced stability under physiological conditions.

Application

Thiol-PEG2-acid serves as a versatile bifunctional linker for conjugation chemistries, combining a reactive thiol group with a terminal carboxylic acid. The PEG2 spacer provides enhanced solubility and reduces steric hindrance, enabling efficient coupling to maleimide-functionalized biomolecules or amine-containing targets via standard EDC/NHS or carbodiimide-mediated activation. Its bench-stable nature and predictable reactivity make it ideal for the synthesis of site-specific bioconjugates, drug delivery systems, and surface-modified nanoparticles.

General Information

  • CAS No. 1379649-73-6
  • Cat. No. CS-0148621
  • Purity ≥95%
  • MDL No. MFCD24503001
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄O₄S
  • Molecular Weight 194.25
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCS

Computational Chemistry Data

  • TPSA   55.76
  • LogP   0.4241
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   8

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS09
Signal Word : Danger
UN#: 3082
Class : 9
Packing Group :
Hazard Statements : H315-H318-H335-H410
Precautionary Statements : P261-P273-P280

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