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1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone

  • CAS No. 1378387-81-5

  • Cat. No. CS-M3016
  • Purity≥98%
  • MDL No.MFCD28400046

*For research and further manufacturing use only, not for direct human use.

1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone|CS-M3016

Structure of 1378387-81-5

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General Information

  • CAS No. 1378387-81-5
  • Cat. No. CS-M3016
  • Purity ≥98%
  • MDL No. MFCD28400046
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₈BrClF₂O
  • Molecular Weight 357.58
  • Synonym(s) 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethan-1-one
  • SMILES ClCC(C1=CC(C(F)(F)C2=C3C=CC(Br)=C2)=C3C=C1)=O

Description

This fluorenone-based ketone features a brominated, difluorinated aryl core paired with a reactive chloroacetyl group. The electron-deficient fluorene scaffold enhances stability and facilitates downstream functionalization. This compound serves as a key intermediate in the synthesis of advanced organic materials and pharmaceuticals requiring precise steric and electronic control.

Application

1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone serves as a versatile building block for C–C and C–heteroatom bond formation in synthetic organic chemistry. The fluorenyl scaffold offers enhanced stability and orthogonal reactivity, while the α-chloroketone functionality enables facile nucleophilic substitution and enolate-mediated coupling reactions. Its bench-stable nature and compatibility with standard purification methods make it suitable for multi-step synthesis of complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   4.9911
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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