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CS-W001157 4
Total: USD 88.00

2-(Thiophen-3-yl)ethanol

  • CAS No. 13781-67-4

  • Cat. No. CS-W002051
  • Purity≥97%
  • MDL No.MFCD00009766

*For research and further manufacturing use only, not for direct human use.

2-(Thiophen-3-yl)ethanol|CS-W002051

Structure of 13781-67-4

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General Information

  • CAS No. 13781-67-4
  • Cat. No. CS-W002051
  • Purity ≥97%
  • MDL No. MFCD00009766
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈OS
  • Molecular Weight 128.20
  • Synonym(s) 3-Thiopheneethanol
  • SMILES OCCC1=CSC=C1

Description

3-Thiopheneethanol [3-(2-hydroxyethyl)thiophene] was used in the synthesis of various ether and ester derivatives such as 3-(2-(benzyloxy)ethyl)thiophene, 3-[2-((triphenylmethyl)oxy)ethyl]thiophene, 3-[2-((trimethylsilyl)oxy)ethyl]thiophene, 3-[2-((dimethyl-tert-butylsilyl)oxy)ethyl]thiophene, 3-(2-acetoxyethyl)thiophene and 3-(2-(benzoyloxy)ethyl)thiophene.

Application

2-(Thiophen-3-yl)ethanol serves as a versatile building block for heterocyclic synthesis, enabling efficient construction of bioactive scaffolds through standard functional group transformations. Its thiophene moiety provides robust aromatic stability and favorable electronic properties, while the terminal primary alcohol facilitates derivatization via oxidation, esterification, or coupling reactions. The compound exhibits excellent bench stability and ease of purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • 3-Thiopheneacetic acid Ticarcillin Impurity|CS-0229739
      6964-21-2
    • ~98%
    • In-stock
      2-(Thiophen-3-yl)ethanol|CS-W002051
      13781-67-4

    References

    • Blaquiere, Nicole; Do, Steven; Dudley, Danette; Folkes, Adrian; Goldsmith, Richard; Heald, Robert; Heffron, Timothy; Kolesnikov, Aleksandr; Ndubaku, Chudi; Olivero, Alan G.; Price, Stephen; Staben, Steven; Wei, BinQing Patent: US2011/76291 A1, 2011 ; Location in patent: Page/Page column 148 ;
  • Route2

    References

    • Schlaeger, Torsten; Oberdorf, Christoph; Tewes, Bastian; Wuensch, Bernhard Synthesis, 2008 , # 11 p. 1793 - 1797
  • Route3
    • null|null
      75-21-8
    • null|null
      1192-06-9
    • ~%
    • In-stock
      2-(Thiophen-3-yl)ethanol|CS-W002051
      13781-67-4

    References

    • Arkiv foer Kemi, , vol. 8, p. 441,445

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.2829
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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