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CS-W001157 4
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5-Bromo-6-methylpicolinic acid

  • CAS No. 137778-20-2

  • Cat. No. CS-W007046
  • Purity≥95%
  • MDL No.MFCD13181588

*For research and further manufacturing use only, not for direct human use.

5-Bromo-6-methylpicolinic acid|CS-W007046

Structure of 137778-20-2

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General Information

  • CAS No. 137778-20-2
  • Cat. No. CS-W007046
  • Purity ≥95%
  • MDL No. MFCD13181588
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₂
  • Molecular Weight 216.03
  • Synonym(s) 2-Pyridinecarboxylic acid,5-bromo-6-methyl
  • SMILES O=C(O)C1=NC(C)=C(Br)C=C1

Description

5-Bromo-6-methylpicolinic acid features a strategically positioned bromine atom and methyl group on the picolinic acid scaffold, enabling direct functionalization in cross-coupling reactions. This electron-deficient heteroaromatic carboxylic acid exhibits enhanced solubility in polar organic solvents and stability under standard bench conditions, making it ideal for use in medicinal chemistry and materials synthesis workflows.

Application

5-Bromo-6-methylpicolinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its ortho-halogenated pyridine core offers high functional group tolerance and bench stability, facilitating efficient derivatization. The methyl group enhances lipophilicity and provides a handle for further modification, making this compound particularly useful in API development and targeted library synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.85072
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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