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Methyl 5-(aminomethyl)pyridine-2-carboxylate dihydrochloride

  • CAS No. 1375471-89-8

  • Cat. No. CS-0218011
  • Molecule weight239.10
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 5-(aminomethyl)pyridine-2-carboxylate dihydrochloride|CS-0218011

Structure of 1375471-89-8

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General Information

  • CAS No. 1375471-89-8
  • Cat. No. CS-0218011
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂Cl₂N₂O₂
  • Molecular Weight 239.10
  • Synonym(s) 5-Aminomethyl-pyridine-2-carboxylic acid methyl ester dihydrochloride
  • SMILES COC(=O)C1=NC=C(C=C1)CN.Cl.Cl

Description

Methyl 5-(aminomethyl)pyridine-2-carboxylate dihydrochloride delivers a pyridyl scaffold with a pendant aminomethyl group, enabling direct functionalization in synthetic sequences. The dihydrochloride salt enhances solubility and stability under standard conditions, facilitating use in medicinal chemistry and peptide conjugation workflows.

Application

Methyl 5-(aminomethyl)pyridine-2-carboxylate dihydrochloride serves as a versatile building block for pyridine-based heterocycles and bioactive scaffolds. The diammonium salt form enhances solubility and stability in polar solvents, facilitating efficient coupling reactions and functionalization at both the pyridine nitrogen and aminomethyl group. Its compatibility with standard amide bond formation, reductive amination, and metal-catalyzed cross-coupling protocols makes it well-suited for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   1.1705
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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